top of page
CarlaOliveiraLab
Laboratory of Post-Transcriptional Control of Gene Expression
The RNA exosome complex is concentrated in the GC compartment of the nucleolus in yeast
Institute of Chemistry
The RNA exosome complex is concentrated in the GC compartment of the nucleolus in yeast
1/9
New Insights into nuclear import and nucleolar localization of yeast RNA exosome subunits. Mol Biol Cell. Neto el al. 2025.
Epub ahead of print. PMID: 40266794.
The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events - Bagatelli et al., 2021. Nucleic acids research.
The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast - Cepeda et al., 2019. J Biol Chem.
This work was reported by the Department of Biochemistry from IQ-USP.
Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA - Navarro et al., 2008. J Biol Chem.
Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae - Gonzales-Zubiate et al., 2017. J Biol Chem.
This work was selected in this special JBC issue.
"Para a professora Carla Columbano de Oliveira, do Instituto de Química (IQ) da USP, não existe uma diferença clara entre o que é pesquisa básica e o que é pesquisa aplicada. Se um cientista não souber o que acontece na célula, argumenta ela, não há maneira de aplicar. E prossegue: 'é uma questão de tempo. Se eu não sei o que a proteína faz, como eu vou desenvolver um medicamento?'".
Publicado: 06/09/2013
bottom of page