Institute of Chemistry
Institute of Chemistry

press to zoom
Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6
Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6

press to zoom
Interaction between splicing factor Cwc24 and R2TP subunit Nop17
Interaction between splicing factor Cwc24 and R2TP subunit Nop17

press to zoom
Institute of Chemistry
Institute of Chemistry

press to zoom
1/7
Bagatelli et al, 2021.jpg
Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA (Protein Data Bank code: 2po1; Navarro MVAS, Oliveira CC, Zanchin NIT, Guimaraes BG. 2008. Insights into the mechanism of progressive RNA degradation by the archaeal exosome. J Biol Chem 283: 14120–14131.
Figura_Exo_Nop.jpg

The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events - Bagatelli et al., 2021. Nucleic acids research.

Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA - Navarro et al., 2008. J Biol Chem.

The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast - Cepeda et al., 2019. J Biol Chem.

This work was reported by the Department of Biochemistry from IQ-USP.

Focus on South America cover_177x229.png
Matéria.png

"Para a professora Carla Columbano de Oliveira,  do Instituto de  Química (IQ) da USP, não  existe uma diferença clara entre o que é  pesquisa  básica e o que é pesquisa aplicada. Se  um  cientista não  souber o que acontece na  célula,  argumenta ela, não há maneira  de  aplicar. E prossegue: 'é uma questão de  tempo. Se eu não  sei  o que a proteína faz,  como eu vou  desenvolver um medicamento?'".

Publicado: 06/09/2013

FAPESP
CNPQ
CAPES

The research is financially supported by FAPESP, CNPq and CAPES grants.

 

Our current financial grant: