Institute of Chemistry
Institute of Chemistry

Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6
Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6

Interaction between splicing factor Cwc24 and R2TP subunit Nop17
Interaction between splicing factor Cwc24 and R2TP subunit Nop17

Institute of Chemistry
Institute of Chemistry

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Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA (Protein Data Bank code: 2po1; Navarro MVAS, Oliveira CC, Zanchin NIT, Guimaraes BG. 2008. Insights into the mechanism of progressive RNA degradation by the archaeal exosome. J Biol Chem 283: 14120–14131.
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"Crystal structure of the Pyrococcus abyssi exosome RNase PH complexed with a single-stranded 10-merpoly(A) RNA" - Navarro MVAS, Oliveira CC, Zanchin NIT, Guimaraes BG. 2008. J Biol Chem 283: 14120–14131.

"The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast" - Leidy Paola P. Cepeda, Felipe F.M. Bagatelli, Renata M. Santos, Marlon D.M. Santos, Fabio C.S. Nogueira e Carla C. Oliveira was reported by Biochemistry Department.

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"Para a professora Carla Columbano de Oliveira,  do Instituto de  Química (IQ) da USP, não  existe uma diferença clara entre o que é  pesquisa  básica e o que é pesquisa aplicada. Se  um  cientista não  souber o que acontece na  célula,  argumenta ela, não há maneira  de  aplicar. E prossegue: 'é uma questão de  tempo. Se eu não  sei  o que a proteína faz,  como eu vou  desenvolver um medicamento?'".

Publicado: 06/09/2013

CNPQ
CAPES

The research is financially supported by FAPESP, CNPq and CAPES grants.

 

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