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Research Articles

BAGATELLI, F. F. M. ; de LUNA VITORINO, F. N. ; DA CUNHA, JULIA PC ; Oliveira, Carla C. . The ribosome assembly factor Nop53 has a structural role in the formation of nuclear pre-60S intermediates, affecting late maturation events. NUCLEIC ACIDS RESEARCH, 2021.


ARANDA, E. E. ; Juliana S. Luz ; Oliveira, Carla Columbano ; PETERSEN, P. ; PETRILLI, H. M. ; FERREIRA, A. M. C. . Heterobinuclear copper(II) platinum(II) complexes with oxindolimine ligands: Interactions with DNA, and inhibition of kinase and alkaline phosphatase proteins. JOURNAL OF INORGANIC BIOCHEMISTRY, v. 203, p. 110863, 2020.

Okuda, E.K., Gonzales-Zubiate, F.A., Gadal, O., Oliveira, C.C. Nucleolar localization of the yeast RNA exosome subunit Rrp44 hints at early pre-rRNA processing as its main function. Journal of Biological Chemistry, 2020

CARVALHO, F. A. ; BARROS, M. R. A. ; GIROTTO, T. P. ; PERONA, M. G. ; Oliveira, Carla C. . Utilization of Grafix for the Detection of Transient Interactors of Saccharomyces cerevisiae Spliceosome Subcomplexes. Jove-Journal of Visualized Experiments, v. 165, p. e61994, 2020.

Cepeda, Leidy Paola P., et al. The ribosome assembly factor Nop53 controls association of the RNA exosome with pre-60S particles in yeast. Journal of Biological Chemistry, 2019.

SILVA, G. H. G. ; DA CUNHA, JULIA PC ; Oliveira, Carla C ; JURICA, M. S. ; Coltri, Patricia P. . Human RNF113A participates of pre-mRNA splicing in vitro. JOURNAL OF CELLULAR BIOCHEMISTRY, v. 120, p. 8764-8774, 2019.

Luz, Juliana S. ; CANEGUIM, B. H. ; BAGGIO, A. ; SANTONI, M. M. ; HELBING, C. C. ; Valentini SR ; SASSO-CERRI, E. ; Oliveira, Carla C . Differential expression of RNA exosome subunits in the amphibian Lithobates catesbeianus during reproductive and non-reproductive periods. BMC RESEARCH NOTES, v. 12, p. 46, 2019.

CAVICCHIOLI, M. ; ZABALLA, A. M. L. ; PAULA, Q. A. ; PRIETO, M. B. ; Oliveira, Carla Columbano ; CIVITAREALE, P. ; CIRIOLO, M. R. ; FERREIRA, A. M. C. . Oxidative Assets Toward Biomolecules and Cytotoxicity of New Oxindolimine-Copper(II) and Zinc(II) Complexes. Inorganics, v. 7, p. 12, 2019.

GONZALES-ZUBIATE, FERNANDO A ; OKUDA, ELLEN K ; DA CUNHA, JULIA PC ; Oliveira, Carla Columbano . Identification of karyopherins involved in the nuclear import of RNA exosome subunit Rrp6 in Saccharomyces cerevisiae. JOURNAL OF BIOLOGICAL CHEMISTRY, v. 292, p. jbc.M116.772376-12284, 2017.


​PRIETO, M. B. ; Georg, Raphaela Castro ; Gonzales, Fernando A. ; Luz, Juliana S. ; Oliveira, Carla C . Nop17 is a key R2TP factor for the assembly and maturation of box C/D snoRNP complex. BMC Molecular Biology, v. 16, p. 7, 2015.

NUNES, C. J. ; BORGES, B. E. ; NAKAO, L. S. ; PEYROUX, E. ; HARDRE, R. ; FAURE, B. ; REGLIER, M. ; GIORGI, M. ; PRIETO, M. B. ; Oliveira, Carla Columbano ; Ferreira, Ana Maria da Costa . Reactivity of dinuclear copper(II) complexes towards melanoma cells: correlation with its stability, tyrosinase mimicking and nuclease activity. Journal of Inorganic Biochemistry, v. 149, p. 49-58, 2015.


MIGUEL, RODRIGO BERNARDI ; PETERSEN, PHILIPPE ALEXANDRE DIVINA ; GONZALES-ZUBIATE, FERNANDO A. ; Oliveira, Carla Columbano ; KUMAR, NARESH ; DO NASCIMENTO, RAFAEL RODRIGUES ; PETRILLI, HELENA MARIA ; DA COSTA FERREIRA, ANA MARIA . Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes. JBIC. Journal of Biological Inorganic Chemistry (Print), v. 20, p. 1205-1217, 2015.

​LOURENÇO, ROGÉRIO F. ; LEME, ADRIANA F. P. ; Oliveira, Carla C. . Proteomic Analysis of Yeast Mutant RNA Exosome Complexes. Journal of Proteome Research (Print), v. 12, p. 5912-5922, 2013.

Johansson, Hans-Olof ; Matos, Tiago ; Luz, Juliana S. ; Feitosa, Eloi ; Oliveira, Carla C. ; Jr, Adalberto Pessoa ; Bülow, Leif ; Tjerneld, Folke . Plasmid DNA partitioning and separation using poly(ethyleneglycol)/poly(acrylate)/salt aqueous two-phase systems. Journal of Chromatography (Print), v. 1233, p. 30-35, 2012.

COLTRI, P. P. ; Oliveira, Carla C . Cwc24p Is a General Saccharomyces cerevisiae Splicing Factor Required for the Stable U2 snRNP Binding to Primary Transcripts. Plos One, v. 7, p. e45678, 2012.

Santos, Marcia C. T. ; Goldfeder, Mauricio B. ; Zanchin, Nilson I. T. ; Oliveira, Carla C. . The Essential Nucleolar Yeast Protein Nop8p Controls the Exosome Function during 60S Ribosomal Subunit Maturation. Plos One, v. 6, p. e21686, 2011.

​da Silveira, Vivian Chagas ; Benezra, Henri ; Luz, Juliana Silva ; Georg, Raphaela Castro ; Oliveira, Carla Columbano ; Ferreira, Ana Maria da Costa . Binding of oxindole-Schiff base copper(II) complexes to DNA and its modulation by the ligand. Journal of Inorganic Biochemistry, v. 105, p. 1692-1703, 2011.

Morello, Luis G. ; Coltri, Patricia P. ; Quaresma, Alexandre J. C. ; Simabuco, Fernando M. ; Silva, Tereza C. L. ; Singh, Guramrit ; Nickerson, Jeffrey A. ; Oliveira, Carla C. ; Moore, Melissa J. ; Zanchin, Nilson I. T. . The Human Nucleolar Protein FTSJ3 Associates with NIP7 and Functions in Pre-rRNA Processing. Plos One, v. 6, p. e29174, 2011.

​de OLIVEIRA, J. F. ; Sforça, M.L. ; BLUMENSCHEIN, T. M. A. ; GOLDFEDER, M. B. ; Guimarães, Beatriz Gomes ; OLIVEIRA, C. C. ; ZANCHIN, N. I. T. ; ZERI, A. C. . STRUCTURE, DYNAMICS AND RNA INTERACTION ANALYSIS OF THE HUMAN SBDS PROTEIN. Journal of Molecular Biology, v. 396, p. 1053-1069, 2010.

Luz, Juliana S ; Barbosa, Joao ARG ; Ramos, Celso RR ; Oliveira, Carla C . Expression, purification and structural analysis of the Pyrococcus abysii RNA binding protein PAB1135. BMC Research Notes, v. 3, p. 97, 2010.

Luz, Juliana S ; Ramos, Celso RR ; Santos, Marcia CT ; Coltri, Patricia P ; Palhano, Fernando L ; Foguel, Debora ; Zanchin, Nilson IT ; Oliveira, Carla C . Identification of archaeal proteins that affect the exosome function in vitro. BMC Biochemistry (Online), v. 11, p. 22, 2010.

Goldfeder, Mauricio B. ; Oliveira, Carla C. . Utp25p, a nucleolar Saccharomyces?cerevisiae protein, interacts with U3 snoRNP subunits and affects processing of the 35S pre-rRNA. The FEBS Journal (Print), v. 277, p. 2838-2852, 2010.

​​LUZ, J. S. ; GEORG, R. C. ; GOMES, C. H. ; Machado-Santelli, GM ; Oliveira, Carla C. . Sdo1p, the yeast orthologue of Shwachman-Bodian-Diamond syndrome protein, binds RNA and interacts with nuclear rRNA-processing factors. Yeast (Chichester), v. 26, p. 287-298, 2009.

DASILVEIRA, V ; OLIVEIRA, C.C. ; GRAZIANI, I ; CIRIOLO, M ; FERREIRA, A . Double-strand DNA cleavage induced by oxindole-Schiff base copper(II) complexes with potential antitumor activity. Journal of Inorganic Biochemistry, v. 102, p. 1090-1103, 2008.

Navarro, M. V. A. S. ; OLIVEIRA, C. C. ; ZANCHIN, N. I. T. ; Guimaraes, B. G. . Insights into the Mechanism of Progressive RNA Degradation by the Archaeal Exosome. The Journal of Biological Chemistry, v. 283, p. 14120-14131, 2008.

Granato, Daniela C.; Machado-Santelli, Glaucia M. . Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosome. The FEBS Journal (Print), v. 275, p. 4164-4178, 2008.

LUZ, J. S. ; TAVARES, J ; GONZALES, F ; SANTOS, M ; OLIVEIRA, C . Analysis of the Saccharomyces cerevisiae exosome architecture and of the RNA binding activity of Rrp40p. Biochimie (Paris), v. 89, p. 686-691, 2007.

MITNENETO, M ; RAMOS, C ; PIMENTA, D ; NISHIMURA, A ; GONZALES, F ; OLIVEIRA, C ; ZATZ, M . A mutation in human VAP-B MSP domain, present in ALS patients, affects the interaction with other cellular proteins. Protein Expression and Purification, v. 55, p. 139-146, 2007.

HESLING, C ; OLIVEIRA, C ; CASTILHO, B . The Shwachman Bodian Diamond syndrome associated protein interacts with HsNip7 and its down-regulation affects gene expression at the transcriptional and translational levels. Experimental Cell Research, v. 313, p. 4180-4195, 2007.


GOLDFEDER, M. B. ; OLIVEIRA, C. C. . Cwc24p, a Novel Saccharomyces cerevisiae Nuclear Ring Finger Protein, Affects Pre-snoRNA U3 Splicing. The Journal of Biological Chemistry, v. 283, p. 2644-2653, 2007.

Guimaraes, B.G. ; Granato, D.C. ; Teixeira, E.C. ; Zanchin, N.I.T. . Structural Insights into the Interaction of the Nip7 PUA Domain with Polyuridine RNA. Biochemistry (Easton), v. 46, p. 14177-14187, 2007.

Ramos, C. R. R.. The Pyrococcus Exosome Complex: STRUCTURAL AND FUNCTIONAL CHARACTERIZATION. The Journal of Biological Chemistry, v. 281, n.10, p. 6751-6759, 2006.

GONZALES, F ; OLIVEIRA, C . Characterization of Nop17p, a Novel Nop58p-Interacting Protein that is Involved in Pre-rRNA Processing. Journal of Molecular Biology, v. 346, p. 437-455, 2005.


Granato, Daniela C.; Gonzales, Fernando A. ; Cassiola, Flavia ; Machado-Santelli, Glaucia M. . Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae. The FEBS Journal, v. 272, p. 4450-4463, 2005.

Guimarães, Beatriz Gomes ; Zanchin, Nilson IvoTonin . Expression, crystallization and preliminary X-ray analysis of the Pyrococcus abyssi protein homologue of Saccharomyces cerevisiae Nip7p. Acta Crystallographica. Section D, Biological Crystallography, v. 60, p. 1925-1928, 2004.

OLIVEIRA, C. C.; F. A. Gonzales ; ZANCHIN, N. I. T. . Temperature-sensitive mutants of the exosome subunit Rrp43p show a deficiency in mRNA degradation and no longer interact with the exosome. Nucleic Acids Research (Online), v. 30, p. 4186-4198, 2002.


​Sandro R. Valentini ; OLIVEIRA, C. C. ; Ann McBride ; Pamela A. Silver . Genetic interactions of yeast eukaryotic translation initiation factor-5A (eIF-5A) reveal connections to poly(A)-binding protein and protein kinase C signaling. Genetics (Austin), v. 160, p. 394-405, 2002.

Lojudice, F.H. ; Silva, D.P. ; ZANCHIN, N. I. T. ; OLIVEIRA, C. C. ; Pessoa Jr., A. . Overexpression of glucose-6-phosphate dehydrogenase (G6PD) in genetically modified Saccharomyces cerevisiae. Applied Biochemistry and Biotechnology, v. 91, p. 161-169, 2001.


OLIVEIRA, C. C.; MCCARTHY, J. E. G. . The relationship between eukaryotic translation and mRNA stability. The Journal of Biological Chemistry (Print), v. 270, n.15, p. 8936-8943, 1995.


STRIPECKE, R. ; OLIVEIRA, C. C. ; MCCARTHY, J. E. G. ; HENTZE, M. W. . Protteins binding to 5´ UTR sites: a general mechanism for translationas regulation of mRNAs in human and yeast cells. Molecular and Cellular Biology (Print), v. 14, n.9, p. 5898-5909, 1994.

OLIVEIRA, C. C.; HEUVEL, J. J. V. D. ; MCCARTHY, J. E. G. . Inhibition of translational initiation in Saccharomyces cerevisiae by secondary structure: the roles of the stability and position of stem-loops in the mRNA leader. Molecular Microbiology (Print), v. 9, n.3, p. 521-532, 1993.

​OLIVEIRA, C. C.; GOOSSEN, B. ; ZANCHIN, N. I. T. ; MCCARTHY, J. E. G. ; HENTZE, M. W. ; STRIPECKE, R. Translational repression by the human iron-regulatory factor (IRF) in Saccharomyces cerevisiae. Nucleic Acids Research, v. 21, n.23, p. 5316-5322, 1993.




non-coding RNAs

Book Chapters

Introdução ao universo dos non-coding RNAs


Chaptel II - snoRNAs (small nucleolar RNAs) 

Profª Drª. Carla Columbano de Oliveira 

Dr. Fernando A. Gonzales-Zubiate

Biotecnologia aplicada à saúde 


Chaptel 26 - Sistema Duplo-Híbrido em levedura

Alina Maria da Silva

Jörg Kobarg

Daniela C. Gonzalez-Kristeller

Carla Columbano de Oliveira



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